| 摘要 |
Compounds of the formula <CHEM> in which: Z is a D or L isomer of Cys; X is Val, Chg, Gln, Cha, Phe, Lys or alpha -MeAA; Y is a D or L-isomer of Pro, Arg, HArg or MeArg, a single bond or, when X is Val, alpha -MeAA, alpha -Mepro, alpha -MeLys or alpha -MeArg; A is a D or L isomer of Tyr, Tyr(Alk), Phe or 4 min -AlkPhe; B is a D or L-isomer of Arg, MeArg or HArg or, when C is Cad, a single bond; C is Gly, Gly(NH2), Cad, OH or NH2; and n is 0 or 1, or a pharmaceutically acceptable salt or ester prodrug thereof, have vasopressin antagonist activity. Methods for their preparation are provided as are compositions containing them. |
