RENAL FUNCTION DIAGNOSTIC LABELED WITH TECHNETIUM-99M

摘要

PURPOSE:To provide a renal function diagnostic containing complex of N-(2- pyridylmethyl)iminodiacetic acid labeled with technetium-99m and exhibiting excellent intake into and excretion from nephroureteral system. CONSTITUTION:N-(2-pyridylmethyl)iminodiacetic acid or its salt is mixed with a pertechnetic acid-reducing agent (preferably water-soluble stannous salt) in a proper solvent and the obtained composition is made to contact with an aqueous solution containing technetium-99m in the form of a pertechnetic acid salt to obtain the objective complex labeled with technetium-99m. The labeled complex is administered usually by intraveneous injection and a part containing nephroureteral system is continuously or intermittently examined by picking up the image of the system or determining the radioactivity with a scintillation scanner or scintillation camera or the radioactivity of the kidney is determined with time using an examination apparatus for renogram. The nucleomedical diagnosis of renal function can be carried out by this process.