| 摘要 |
The use of substd. catechol derivs. of formula (Ia), their physiologically hydrolysable esters and ethers, and pharmaceutically acceptable salts as therapeutic agents is new. Ra = NO2 or CN; Rb = H or halo; Rc = halo, NO2, CN, -(A)n-(Q)m-R1 or -(A)n-Q-R2; A = vinylene, opt. substd. by lower alkyl; n and m = zero or 1; R1 = COR3, aromatic carbocyclic gp. or, bonded via a C atom, an aromatic or partially unsatd. heterocycle; R2 = H or lower hydrocarbyl, opt. substd., satd. or partially unsatd.; R3 = OH; NH2; lower hydrocarbyl (opt. substd., satd. or partially unsatd.) bonded via O, imino or lower alkylimino; or an N-bound, satd. N-contg. heterocyclyl; Q = CO or C=N-(Z)p-R4; Z = O or imino; P = zero or 1; R4 = H or a satd. or partially unsatd. lower hydrocarbyl, opt. substd. and opt. bound via carbonyl gp. (Ia) are new cpds. when R = NO2, CN, -(A)n-(Q)m-R1 or -(A)n-Q-R21; R21 is as R2, excluding H; provisos: Ra = CN if Rc = CN or NO2; R3 is other than OH when m = zero. |
