发明名称 PENEM DERIVATIVES
摘要 There are provided compounds of formula I: <IMAGE> (I) wherein R1 is hydrogen or a C1-C4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy or halogen atom; R2 is a free or esterified carboxy group or carboxylate anion; R3 and R4 are each independently hydrogen or organic group, X is -O-, <IMAGE> +TR <IMAGE> -S-, Q is either (a'') free or protected hydroxy, or (b'') a C1-C1 acyloxy, or (c'') carbamoyloxy OCONH2, or (d'') an optionally substituted heterocyclylthio group, or (e'') an optionally substituted imido group, or (f'') an optionally substituted quaternary ammonium group or (g'') a halogen atom, A and the pharmaceutically or veterinarily acceptable salts thereof. There are provided also methods for preparing compounds of formula I. The compounds of formula I are useful as antibacterial agents.
申请公布号 AU6963187(A) 申请公布日期 1987.09.10
申请号 AU19870069631 申请日期 1987.03.03
申请人 FARMITALIA CARLO ERBA S.P.A. 发明人 ETTORE PERRONE;MARCO ALPEGIANI;ANGELO BEDESCHI;FRANCO ZARINI;CONSTANTINO DELLA BRUNA;GIOVANNI FRANCESCHI
分类号 C07D237/00;A61K31/43;A61K31/431;A61K31/435;A61K31/495;A61K31/50;A61K31/505;A61K31/53;A61P31/04;C07D499/04;C07D499/06;C07D499/861;C07D499/88;C07D499/897;C07D519/00;C07D519/06 主分类号 C07D237/00
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