摘要 |
<p>The compounds of the present invention comprise substituted phenolic thioethers represented by the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="61" wi="132" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein: R₁ and R₂ are the same or different and independently represent <Underline style="single">tert</Underline>-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, -NH- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R₃ represents CO₂H, CO₂-alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are specific inhibitors of 5-lipoxygenase and, therefore, are usefull in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved. </p> |