| 摘要 |
Cytotoxic medicaments which contain compounds of the formula I <IMAGE> or a physiologically tolerable salt thereof, where in the formula I R denotes a saturated or unsaturated hydrocarbon radical having 12 to 24 C atoms, which can also be halogen-substituted, X is an oxygen atom, NH or NR2 and Y is an oxygen atom or NH, R1 is a C1-C8-alkyl group, or in which R1 represents a C2-C8-alkyl group which is unsaturated and/or substituted by halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxyl, carboxyl, C3-C8-cycloalkyl or phenyl, and in which R1 can additionally also denote 2-tert-butoxycarbonylaminoethyl, 2-tert-butoxycarbonylethyl, 2,3-isopropylidenedioxyprop-1-yl, 2,3-dibenzyloxyprop-1-yl, 1,3-dibenzyloxyprop-2-yl or N-C1-C6-alkylamino-C2-C6-alkyl when X is an oxygen atom, and in which R1 can additionally also denote 2,3-dihydroxyprop-1-yl when X is the NH group, and R2 represents a 2,3-dihyroxyprop-1-yl group, a C1-C8-alkyl group or a C2-C8-alkyl group which is unsaturated and/or substituted by halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxyl, carboxyl, C3-C8-cycloalkyl or phenyl, compounds of the formula I and processes for their preparation.
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