| 摘要 |
Dihydropyrazolo[3,4-b]pyridine derivatives represented by the general formula: <CHEM> wherein X and X<1> each is hydrogen, nitro, or halogen which may be located at the position or positions 2, 3, and or 6; R<1> is alkyl; R<2> is hydrogen, alkyl, cycloalkyl, or phenyl; R<3> is hydrogen, straight or branched chain alkyl, or cycloalkyl which may be substituted by alkyl, substituted or unsubstituted phenyl, aralkyl, alkoxycarbonyl, or 5- or 6-membered heterocyclic group containing an oxygen or nitrogen, having calcium antagonistic action are useful in treatment of diseases in the circulatory system such as angina pectoris, hypertension, cerebrovascular dysfunction, arrhythmia, and so on with no adverse reaction like negative inotropic action; prepared by the Michael addition and concurrent cyclization reaction of 2-acetyl cinnamic acid derivatives with 5-aminopyrazole derivatives. |
