| 摘要 |
NEW MATERIAL:A compound shown by formula I [R is OH, halogen, alkanoyloxy, R4-carbamoyloxy (R4 is alkyl or aryl), 1-imidazolyl, morpholino, group shown by formula II (R5 is H or R4; m is 4-6), group shown by formula III, etc.; A is alkylene; R1 is alkyl, (substituted) alkyl or (substituted) phenyl- alkyl; R2 and R3 are alkyl or R2 and R3 are bonded to form tetramethylene] and a salt thereof. EXAMPLE:1-(2-Hydroxyethyl)-3,5,6-trimethyl-2-oxo-1,2-dihydropyrazine. USE:Having an inhibitory action on blood platelet aggregation, vasodilating action and/or inhibitory action on peroxide lipid formation and useful as a drug for improving circulation and metabolism. PREPARATION:For example, a compound shown by formula II is reacted with a hydroxyalkyl halide shown by formula III (X is halogen) to give a compound shown by formula R=OH. |
