5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PROSTAGLANDIN I.SUB.2 DERIVATIVE

摘要

TITLE OF THE INVENTION: 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PROSTAGLANDIN I2 DERIVATIVE A compound of the formula < IMG > (I) wherein R1 is a pharmaceutically acceptable cation, hydrogen or n-alkyl of 1 to 12 carbon atoms; R2 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R3 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R4 is hydrogen, methyl or ethyl; R5 is n-alkyl of 1 to 5 carbon atoms; n is an integer of 0 to 4; A is -CH2-CH2- or trans -CH=CH-; and X is -CH2-CH2- or trans -CH=CH-.