| 摘要 |
Compounds of formula I: <IMAGE> I wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen or halogen atom or a methyl, cyano, C1-C4 alkylthio or phenylthio group; R7 and R8 represent hydrogen atoms and R3 represents a hydrogen atom or a methoxy group, or R7 represents a hydrogen atom and R3 and R8 taken together represent a bond, or R3 represents a hydrogen atom or a methoxy group and R7 and R8 taken together represent a bond; R4 represents a hydrocarbon group having from 1 to 4 carbon atoms; R5 represents a hydrogen atom or a hydrocarbon group having from 1 to 4 carbon atoms or a phenyl group; X represents an oxygen or sulphur atom or an imino group, R9 represents a hydrogen atom and B represents a cyano, a C2-C5 alkoxycarbonyl or carbamoyl group, or R9 and B taken together represent a <IMAGE> group wherein W represents an oxygen atom or an imino group; A represents a group of the formula CHR6, CH2-CHR6 or CH=CR6 group wherein R6 represents a hydrogen atom or a C1-C4 alkyl group; and n is 0, 1 or 2; and their pharmaceutically acceptable salts are disclosed, along with the use of these compounds as antiprolactinic and antihypertensive agents. The preparation of these compounds and pharmaceutical compositions containing them are also described.
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