| 摘要 |
<p>Novel compounds of the formula: R-O-CO-X-CO-Z wherein R is a dimeric indole-dihydroindole radical derived from a 4-acetoxy or 4-hydroxy antineoplastic dimeric indole-dihydroindole alkaloid, wherein Z is a carboxy activating group (Z<1>) or a carboxy protecting group (Z<2>), and wherein X is C1-4 straight chain alkylene, C2-8 branched alkylene, C2-4alkenylene, C3-4alkynylene, C3-6cycloalkylene, phenylene, hydroxy-substituted C1-4alkylene or a direct bond, and salts thereof, are intermediates in the preparation of active vinca derivatives or can be used in the preparation of immunoglobulin conjugates.</p> |
