3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them.

摘要

A compound of formula (1) or a pharmaceutically acceptable salt thereof:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="67" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>R, is hydrogen, C<Sub>1-6</Sub> alkyl, C<Sub>1-6</Sub> alkoxy or halogen;</ListItem><ListItem>R<Sub>2</Sub> and R<Sub>3</Sub> are both hydrogen or together represent a bond;</ListItem><ListItem>R<Sub>4</Sub> is selected from C<Sub>1-6</Sub> alkyl, phenyl, phenyl-C<Sub>1-4</Sub> alkyl, CORe where R<Sub>8</Sub> is hydroxy, C<Sub>1-6</Sub> alkoxy or NR<Sub>9</Sub>R<Sub>10</Sub> where R<Sub>9</Sub> and R<Sub>10</Sub> are independently hydrogen or C<Sub>1-4</Sub> alkyl and CH<Sub>2</Sub>OR<Sub>11</Sub> where R<Sup>11</Sup> is hydrogen, C<Sub>1-4</Sub> alkyl or C<Sub>1-4</Sub> alkanoyl;</ListItem><ListItem>R<Sub>6</Sub> is hydrogen, C<Sub>1-6</Sub> alkyl or phenyl C<Sub>1-4</Sub> alkyl;</ListItem><ListItem>R<Sub>6</Sub> is phenyl C<Sub>1-7</Sub> alkyl in which the phenyl moiety is optionally substituted by one or two of halogen, ortho-nitro. meta-or para-methoxy, methyl or NR<Sub>12</Sub>R<Sub>13</Sub> wherein R<Sub>12</Sub> and R<Sub>1</Sub>3
are independently hydrogen or C<Sub>1-6</Sub> alkyl or R<Sub>12</Sub> and R<Sub>13</Sub> together are C<Sub>2-6</Sub> polymethylene or the phenyl moiety is 3,4- disubstituted by methylenedioxy or ethylenedioxy; and</ListItem><ListItem>R<Sub>7</Sub> is hydrogen or C<Sub>1-4</Sub> alkyl, processes for its preparation and its use as a pharmaceutical.</ListItem></UnorderedLists>