摘要 |
NEW MATERIAL:A substituted aminobenzylsulfonylbenzimidazole compound of formula I (R<1> is H, alkyl, cycloalkyl, phenyl or aralkyl; R<2> is H, alkyl or R<1> and R<2> together with adjacent N form a ring; R<3> and R<4> are H, halogen, CF3, alkyl, alkoxy, alkoxycarbonyl or amino). EXAMPLE:2-(2-Dimethylaminobenzylsulfonyl)benzimidazole. USE:An antiulcer agent having excellent effect to suppress gastric acid secretion and exhibiting high stability in acidic solution. It has desirable characteristics as an agent for oral administration. PREPARATION:The objective compound of formula I can be produced e.g. by reacting the 2-mercaptobenzimidazole compound of formula IV with the 2-aminobenzyl compound of formula V to obtain the compound of formula III, oxidizing the compound to the compound of formula II and further oxidizing the product.
|