发明名称 SUBSTITUTED AMINOBENZYLSULFONYLBENZIMIDAZOLE COMPOUND
摘要 NEW MATERIAL:A substituted aminobenzylsulfonylbenzimidazole compound of formula I (R<1> is H, alkyl, cycloalkyl, phenyl or aralkyl; R<2> is H, alkyl or R<1> and R<2> together with adjacent N form a ring; R<3> and R<4> are H, halogen, CF3, alkyl, alkoxy, alkoxycarbonyl or amino). EXAMPLE:2-(2-Dimethylaminobenzylsulfonyl)benzimidazole. USE:An antiulcer agent having excellent effect to suppress gastric acid secretion and exhibiting high stability in acidic solution. It has desirable characteristics as an agent for oral administration. PREPARATION:The objective compound of formula I can be produced e.g. by reacting the 2-mercaptobenzimidazole compound of formula IV with the 2-aminobenzyl compound of formula V to obtain the compound of formula III, oxidizing the compound to the compound of formula II and further oxidizing the product.
申请公布号 JPS62192366(A) 申请公布日期 1987.08.22
申请号 JP19860034058 申请日期 1986.02.18
申请人 NIPPON CHEMIPHAR CO LTD 发明人 OKABE SUSUMU;SATO MASARU;YAMAKAWA TOMIO;NOMURA YUTAKA;HAYASHI MASATOSHI
分类号 C07D235/28;A61K31/415;A61K31/4184;A61P1/04 主分类号 C07D235/28
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