| 摘要 |
PURPOSE:To provide an aqueous solution containing scopolamine hydrobromide and having improved stability of the solution, by adding taurine under neutral pH condition. CONSTITUTION:An aqueous solution of scopolamine hydrobromide is compounded with taurine and optionally glycerol or sorbitol at 5-6 pH. The stability of scopolamine hydrobromide is highly dependent upon the pH of its aqueous solution and is high at 3-4 pH. However, the stability, especially hydrolysis stability of scopolamine hydrobromide causes a problem when an aqueous solution of neutral pH (i.e. 5-6 pH) is to be prepared. The hydrolysis of scopolamine hydrobromide can be suppressed by the addition of taurine or taurine and glycerol, etc. The amount of taurine is preferably e.g. 0.02-0.2 M concentration.
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