发明名称 |
2,3,4,8,9,9a-Hexahydro-4-aryl-1H-indeno¬1,7-cd azepines |
摘要 |
<p>Compounds of structure (I)
<CHEM>
in which Ar is furyl, thienyl, phenyl or phenyl which is substituted with 1 or 2 methoxy, hydroxy, halo or methyl groups; R is hydrogen, C3-6 allyl or C1-4-alkyl; and R<1> and R<2> are, each, hydrogen, C1-4alkoxy, hydroxy, halo or trifluoromethyl, at least one of R<1> and R<2> being other than hydrogen, and pharmaceutically acceptable acid addition salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as dopamine antagonists. </p> |
申请公布号 |
EP0233049(A1) |
申请公布日期 |
1987.08.19 |
申请号 |
EP19870300970 |
申请日期 |
1987.02.04 |
申请人 |
SMITHKLINE BECKMAN CORPORATION |
发明人 |
KAISER, CARL;OH, HYE-JA;WEINSTOCK, JOSEPH |
分类号 |
C07D409/04;A61K31/55;A61P25/00;A61P43/00;C07D223/32;(IPC1-7):C07D223/32;C07D405/04 |
主分类号 |
C07D409/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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