| 摘要 |
PURPOSE:To obtain the titled compound useful as an anticoagulant, etc., in high purity, simply and efficiently, by dissolving a protamine mineral acid salt obtained from milt of fish in warm water, adding a small amount of a sulfate to the warm solution in water and cooling. CONSTITUTION:Firstly, a protamine mineral acid salt is extracted from milt of fish by a well-known method, separated and dissolved in warm water usually at 40-50 deg.C. Then the warm solution in water is blended with a small amount of a sulfate, preferably 0.005-0.2mol based on 1l warm solution of the sulfate and cooled to precipitate the aimed compound. The warm solution is preferably cooled to <=5 deg.C.
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