| 摘要 |
NEW MATERIAL:A compound shown by formula I (R is trimethyl, lower acyl or monohalogen-substituted benzoyl; X is halogen, lower alkyl or trifluoromethyl). EXAMPLE:5-Trifluoromethyl-3'-O-thiobenzoyl-5'-O-trityl-2'-deoxy-beta-u ridine. USE:An intermediate for synthesizing a 3'-O-benzyl-2'-deoxy-beta-uridine shown by formula II as a carcinostatic agent. Inexpensively producible. PREPARATION:For example, a 2-deoxy-3-O-thiobenzoyl-D-ribofuranose derivative shown by formula III is reacted with a pyrimidine derivative shown by formula IV in a mol equivalent ratio of preferably 1:1-3 usually in a solvent such as benzene, etc., at <= freezing point - <= room temperature.
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