3-Phenoxy(or phenylthio)cyclopentanecarbonylamino acid analogues.

摘要

This invention relates to compounds presented by the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="44" wi="110" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> [wherein R¹ and R² are:
(i) R¹, R² and carbon atoms to which R¹ and R² are linked, together represent the group of the general formula:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="21" wi="34" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> (wherein R⁵ and R⁶ represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl or phenyl, independently, with the proviso that R⁵ and R⁶ is not hydrogen atoms at the same time), or
(ii) R¹ represents hydrogen and R² represents the group of the formula: -COR⁷ (wherein R⁷ represents the group of the formula: <!-- EPO <DP n="47"> --><Chemistry id="chema03" num="0003"><Image id="ia03" he="47" wi="108" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> (wherein Y represents a single-bond, alkylene, alkenylene, W represents oxygen or sulfur, m represents 1 to 3, R⁸ represents hydrogen, halogen, nitro, hydroxy, alkyl or alkoxy, with the proviso that when m represents more than two, plural R⁸s may be different each, and R⁹ represents hydrogen, alkyl or phenyl group, with the proviso that two of R⁹ may be different each)), R³ represents hydrogen, halogen, alkyl group or two of R³ and phenyl to which two of R³ are linked, together represent naphthyl of the formula:
<Chemistry id="chema04" num="0004"><Image id="ia04" he="30" wi="28" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> (wherein R¹⁰ represents hydrogen, halogen or alkyl), with the proviso that when R¹ represents hydrogen, the atom may be replaced by R³, and n represents 1 to 3, with the proviso that when n represents two or more, plural R³s may be different each, X represents oxygen or sulfur and R⁴ represents amino acid-residue], or a non-toxic salt thereof, and methods for their preparation and treating agents for cerebral edema containing them as active ingredients.