| 摘要 |
PURPOSE:To obtain the titled antibiotic useful as a feed additive for the purpose of growth promotion of animal, improving effect on feed efficiency, etc., by cultivating a bacterium capable of producing nosiheptide in a medium containing zinc, nickel or its compound. CONSTITUTION:A bacterium [e.g., Streptomyces actousus 40037, NRRL-2954), etc.,] capable of producing nosiheptide is cultivated in a medium containing preferably 0.0005-1wt% at least one selected from zinc, nickel and their compounds (e.g., ZnSO4.7H2O, ZnCl2, NiCl2, etc.,) preferably under an aerobic condition at 25-33 deg.C at pH 6.0-8.0 to give to aimed sulfur-containing polypeptide. antibiotic. |
