发明名称 |
Process for making chiral 1 beta-methyl-carbapenem intermediates. |
摘要 |
<p>A multistep process is described for selectively obtaining 1- beta -methylcarbapenem intermediates in high overall yield. The desired 1- beta -methyl chirality is obtained through the hydrogenation of certain bicyclic beta -lactam ring structures containing an exocyclic methylene double bond alpha to the beta -lactam ring, in the presence of a metallic nickel hydrogenaton catalyst. The hydrogenation results in a mixture of alpha - and beta -methyl isomers having a high beta / alpha epimeric molar ratio. New 1- beta -methylcarbapenem intermediates containing the exocyclic double bond are also described.</p> |
申请公布号 |
EP0230792(A1) |
申请公布日期 |
1987.08.05 |
申请号 |
EP19860310225 |
申请日期 |
1986.12.31 |
申请人 |
MERCK & CO. INC. |
发明人 |
SHINKAI, ICHIRO;KING, ANTHONY ON-PING;FUENTES, LELIA M. |
分类号 |
C07D205/08;C07D498/04;C07F7/18;(IPC1-7):C07D205/08;C07F11/00 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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