发明名称 |
Method of separating proteins from aqueous solutions |
摘要 |
There is disclosed an improved method for separating and recovering proteins, particularly therapeutically active proteins, from an aqueous system also containing a component having the ability to create two liquid phases by use of salt partitioning technology. By the addition of water soluble inorganic salts to an aqueous system containing one or more therapeutically active proteins or nucleic acids, especially an aqueous system obtained from fractionation of a blood plasma fraction or from a tissue culture fluid resulting from a biotechnology production operation such as recombinant DNA and monoclonal antibody technologies, the aqueous system may be separated into two or more liquid phases. Such separated phases may be selectively enriched in components of the original aqueous system having differing solubility in the so-separated liquid phases.
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申请公布号 |
US4684723(A) |
申请公布日期 |
1987.08.04 |
申请号 |
US19850774677 |
申请日期 |
1985.09.11 |
申请人 |
MILES LABORATORIES, INC. |
发明人 |
DOVE, GEORGE B.;MITRA, GAUTAM |
分类号 |
A61K35/14;A61K31/70;A61K35/16;A61K38/00;A61K38/16;A61K38/21;A61K38/55;A61K39/395;C07K1/14;C07K14/47;C07K14/76;C07K14/765;C07K14/81;C07K16/00;C07K16/06;C12P19/34;(IPC1-7):C07G7/00 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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