| 摘要 |
<p>Lipoxygenase inhibitor (LPI) comprises, as active ingredient, a styrene deriv. (A) having a radical of formula (I) and contg. at least 8C (pref. at least 12C). In (I), X=OH or lower alkoxy (pref. of 1-4C); q=2 or 3. Pref. styrene deriv. (A) is of formula (A1); where Z=COOR1, COZ1Ar, CONHCmH2m+1, CO(CH2)lR4 or CpH2pR5; R1=3-10C alkyl opt. substd. by halo(s); Z1=O(CH2)nCH=CH-, NH-(CH2)nCH=CH, or NH(CH2)n; n=1-4; Ar=phenyl substd. by R2 and R3; R2 and R3=H, lower alkoxy or OH; m=6-14, R4=phenyl opt. substd. by OH, lower alkoxy or halo, l=0-7, provided that it is not 0 when R4=Ph; R5=H or phenyl substd. by R6 and R7; R6 and R7=H, OH, lower alkoxy or halo, p=1-8 when R5=H, p=0-5, when R5=C6H3R6R7.</p> |
