| 摘要 |
PT--81819 A 2-Phenylalkoxyalkyl amino-1-(3-substd.-amino-4 -hydroxy phenyl)ethanol derivs. and analogues of formula (I) and their salts and solvates are new. Ar = Ph opt. substd. by halogen, 1-6C alkyl, 1-6C alkoxy, NO2, (CH2)qR, (CH2)rR10, O(CH2)tR11 or by a O(CH2)pO gp.; R = OH NR3R4, NR5COR6, NR5SO2R7, COR8, SR9, SOR9, SO2R9 or CN; q = 0-3; R3-R5 = H or 1-4C alkyl; or NR3R4 = 5- to 7-membered satd. heterocyclylic amino opt. contg. in the ring one or more O, S, NH or NMe; R6 = H, 1-4C alkyl, 1-4C alkoxy, Ph or NR3R4; R7 = 1-4C alkyl, Ph or NR3R4; R7 = 1-4C alkyl, Ph or NR3R4; R8 = OH, 1-4C alkoxy or NR3R4; R9 = H, 1-4C alkyl or Ph; R10 = 1-4C alkoxy; r = 1-3; R11 = OH or 1-4C alkoxy; t = 2 or 3; p = 1 or 2; R1, R2 = H Or 1-3C alkyl, provided that R1+R2 do not contain over 4C; X = 1-7C alkylene, 2-7C alkenylene or 2-7C alkynylene or 2-6C alkynylene, provided that X-Y contain 2-10C; Q = R12CO, R12NHCO, R12R13NSO2 or R14SO2; R12, R13 = H Or 1-3C alkyl; R14 = 1-4C alkyl.
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