| 摘要 |
NEW MATERIAL:A piperazine derivative expressed by the formula (Y is pyrrolidyl, piperidyl, morpholyl or lower alkylamino). EXAMPLE:1-[5-(3, 5-Dimethoxy-4-hydroxyphenyl)-2,4-pentadienoyl]-4-(N-isopropy laminocarbonylmethyl)piperazine. USE:A vasodilator. PREPARATION:Thiazolidinethionamide or 5-(3,5-dimethoxy-4-methoxymethoxy phenyl)-2,4-pentadienoic acid is reacted with piperazine to give 1-[5-(3,5- dimethoxy-4-methoxymethoxyphenyl)-2,4-pentadienoy-l]pipe razine, which is then condensed using chloroacetamide and then demethoxymethylated with an acid to afford the aimed compound expressed by the formula. |
