Method for preparing liposomes containing a lipophilic active substance, in particular amphotericin, and liposomes and new medicament which are obtained

摘要

The invention relates to a method for preparing unilamellar liposomes of specified lipid composition containing a lipophilic active substance, which method entails the following successive steps: a. Manufacturing empty liposomes; b. Bringing the empty liposomes and the pulverulent lipophilic active substance into contact; c. Sonicating the mixture of liposomes and pulverulent lipophilic active substance to enable the aforementioned substance to be incorporated in the liposomes; and d. Where appropriate, isolating the loaded liposomes. e