| 摘要 |
<p>The protein PP4 which has a) an electrcphoretic mobility in the range between that of ?1 and ?2 globulins; b) an isoelectric point of 4.85 + 0.15; O c) a sedimentation coefficient s 20 w of 3.3 ~ 0.2S; d) a molecular weight determined in polyacrylamide gel containing sodium dodecylsulfate (DSD) of 35,000 + 5,000; 1% e) an extinction coefficient E 1cm (280 nm) of 5.9 + 0.6; f) a carbohydrate content of 2.4 + 0.94% (g/100 g) (mannose 0.3 + 0.2%, galactose 0.4 + 0.2%, xylose 0.1 + 0.4%, glucose 0.2 0.1%, glucosamine 1.0 + 0.2% and neuraminic acid 0.4 + 0.2%) and g) a specified aminoacid composition, and a process for its preparation are described. PP4 can be used to prepare antisera which can be employed to detect and determine PP4 in body fluids in order to diagnose diseases of particular organs, as a "marker" to monitor the progress of a disease or to check therapy.</p> |
