| 发明名称 |
Orally active phosphonyl hydroxyacyl prolines and processes for preparing phosphonyl hydroxyacyl prolines. |
| 摘要 |
<p>Processes are disclosed for preparing phosphonyl hydroxyacyl prolines from a phosphonous acid or phosphonochloridate intermediate. The compounds prepared possess angiotension converting enzyme inhibition activity and are useful as antihypertensive agents.
<??>This invention is also directed to orally active antihypertensive agents of the formula
<CHEM>
wherein R1 is certain alkyl or aralkyl groups. </p> |
| 申请公布号 |
EP0229520(A1) |
申请公布日期 |
1987.07.22 |
| 申请号 |
EP19860310043 |
申请日期 |
1986.12.22 |
| 申请人 |
E.R. SQUIBB & SONS, INC. |
发明人 |
KARANEWSKY, DONALD STEVEN;PETRILLO, EDWARD WILLIAM, JR. |
| 分类号 |
A61K31/675;A61P9/12;A61P43/00;C07F9/38;C07F9/40;C07F9/547;C07F9/572 |
主分类号 |
A61K31/675 |
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