发明名称 |
PROCESS FOR PREPARATION OF CYCLIC DITHIODIACETAMIDES |
摘要 |
The present invention relates to a process for preparation of cyclic dithiodiacetamides with action inhibiting the malformation or the destruction of the red blood corpuscles due to a genetic modification of the haemoglobin or to parasites, of formula : < IMG > in which X is a direct bond, an atom of oxygen or of sulfur, a methylene group, an ethylene group or an N-R group, where R is an atom of hydrogen or a lower alkyl group, lower (hydroxy)alkyl group, lower alkanoyl group or a phenyl group ; or their possible pharmaceutically acceptable salts ; said process comprising the step of reacting a dithiodiacetate or a mercaptoacetate of lower alkyl with a cyclic secondary amine, optionally oxiding the resulting compound and converting it into a pharmaceutically acceptable salt. |
申请公布号 |
CA1224462(A) |
申请公布日期 |
1987.07.21 |
申请号 |
CA19840454452 |
申请日期 |
1984.05.16 |
申请人 |
STYLED SANOFI SA;INST NAT SANTE RECH MED |
发明人 |
ROSA, JEAN;CASTAIGNE, JEAN-PAUL;DEMARNE, HENRI;TOZZOLINO, PIERRE |
分类号 |
C07D295/18;A61K31/395;A61K31/40;A61K31/535;A61K31/5375;A61P7/00;A61P7/06;A61P33/02;C07D295/185 |
主分类号 |
C07D295/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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