| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for a carcinostatic agent, a germicide, an antihypertensive, etc., by an easier method with respect to operation than a well-known method and in high yield, by hydrolyzing a 4-amino-2(5H)-furanone derivative under a strongly acidic condition. CONSTITUTION:A 4-amino-2(5H)-furanone derivative shown by formula I (R<1> and R<2> are H, lower alkyl, phenyl or benzyl, or a case wherein R<1> is bonded to R<2> at end to form a polymethylene chain is included; R<3> is H, lower alkyl or CF3) is hydrolyzed by the use of hydrochloric acid, sulfuric acid, phosphoric acid, etc., at pH<=2, preferably pH<=1 to give the aimed compound shown by formula II industrially advantageously. The compound shown by formula I can be readily produced from a compound shown by formula III (R<1>' is each group in R<1>; R<2>' is each group in R<2> except H) and a compound shown by formula IV (R<4>-R<6> are methyl, ethyl or t-butyl).
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