| 摘要 |
NEW MATERIAL:An antitumor component: SPF 10-12 [elementary analyses: C 41.3-43.5%, H 5.9-6.7%, N 14.2-16.6%, O 37.9-31.4%, Ash 0.7-1.8%; decomposition point: browning at 165 deg.C and darkening at 240 deg.C with decomposition; specific rotatory power: [alpha]<20>D=-80 deg.--95 deg. (C=1.00); pH is 5.5-6.0 in 0.1 aqueous solution; color: pale brown; color reaction: positive to the Rowry reaction, negative to orcinol-hydrochloric reaction; molecular weight: 10,000-40,000 (according to the gel-filtration method); solubility: soluble in water, sparingly soluble or insoluble in methanol, etc.] USE:Antitumor agent. PREPARATION:A microorganism in Streptococcus, capable of producing an antitumor component, SPF 10-12, is cultured and penicillin or its relating substance is added to the culture mixture in an appropriate period. The cell bodies are centrifuged off and the filtrate is concentrated and purified to give the objective antitumor agent, SPF 10-12. |
