OPTICAL RESOLUTION OF (+-)-2-METHYLPENTANOIC ACID

摘要

PURPOSE:To separate (+ or -)-2-methylpentanoic acid into the titled (+)- or (-)- compound with a solvent, by reacting a specific optical resolving agent with (+ or -)-2-methylpentanoic acid to carry out optical resolution in high purity and yield and utilizing the solubility difference of the resultant salts. CONSTITUTION:(+ or -)-2-Methylpentanoic acid is reacted with optically active 1-phenyl-2-(p-tolyl)ethylamine as an optical resolving agent to carry out optical resolution and form a salt of (+)-2-methylpentanoic acid and salt of (-)-2- methylpentanoic acid. The solubility difference between them is utilized to separate the titled compound into the salt of the (+)-2-methylpentanoic acid and salt of the (-)-2-methylpentanoic acid. The optical active substances can be utilized as an optical resolving agent and is capable of readily synthesizing optically active 2-methylpentanol by reduction or various optically active derivatives by ester bonds or amide bonds, etc.