发明名称 PROCESS FOR THE PREPARATION OF TETRAHYDRO IMIDAZOQUINAZOLINE DERIVATIVES
摘要 The title compds. of formula (I) or its pharmaceutically acceptable salts are new. (I) are prepd. by reacting (II) with Het-Zn-Cl in the presence of tetrakis (triphenylphosphine) Pd(o) catalyst at 25-80 deg. C. In the formula, Het is imidazolyl or triazolyl gp. (opt. subst. by 1-2 methyl), pyridyl gp. (opt. substd. by 1-2 methyl or hydroxy); R, R1, R2, R3, R4 and R5 are H or CH3 ; Q is leaving gp.. (I) are useful for treatment of cardic insufficiency.
申请公布号 KR870001362(B1) 申请公布日期 1987.07.20
申请号 KR19860004434 申请日期 1986.06.04
申请人 PFIZER CORP. 发明人 CAMBELL SIMON FRASER;ROBERTS DAVID ANTHONY
分类号 C07D487/14;C07D213/64;C07D249/08;C07D487/04;C07D521/00;(IPC1-7):C07D487/04 主分类号 C07D487/14
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