3(2H)-PYRIDAZINONE DERIVATIVE, DRUG COMPOSITION AND MANUFACTURE

摘要

The subject-matter of the invention are 3(2H)-Pyridazinone derivatives of the general formula wherein R stands for an ethyl or propyl group substituted by a terminal halogen atom or hydroxyl group or a terminal group of the formula in which latter R1 represents a hydrogen atom or an optionally substituted benzyl group and R2 represents a hydrogen atom or an optionally substituted benzoÄ1,4Üdioxan-2-yl-methyl or benzoÄ1,4Üdioxan-2-yl-ethyl group or a group of the formula in which latter n is 2 or 3 and R3 stands for an optionally substituted phenoxy or phenylthio group and X stands for a hydrogen or halogen atom or an optionally substituted saturated or unsaturated 5- or 6-membered heterocyclic group. Furthermore the subject-matter of the invention are a process and intermediates for preparing these compounds and medicaments containing them and/or other 3(2H)-pyridazinone derivatives. The compounds according to the invention inhibit the adrenergic alpha1 receptors, have a calcium-antagonistic effect and exert blood pressure lowering action.