| 摘要 |
Pyrimidine derivatives of the formula <CHEM> or a pharmaceutically acceptable salt thereof, wherein R is <CHEM> 2-chloroethyl, C3-C8 cycloalkyl, phenoxy-substituted C1-C4 alkyl, or norbornan-2-yl. R1 is methyl, trifluoromethyl, methoxy, fluoro, chloro, bromo, or nitro; R2 is hydrogen, methyl, trifluoromethyl, methoxy, fluoro, chloro, bromo, or nitro; each of R3 and R4 is independently hydrogen, methyl, methoxy, fluoro, or chloro; and X is hydrogen, hydroxy, methyl, or halo, with the proviso that if R1 is methoxy, R must be substituted phenyl with at least one of R3 and R4 being other than hydrogen inhibit aromatase and are useful in treating or preventing estrogen-dependent diseases in mammals. |
