| 摘要 |
PURPOSE:To obtain the titled granule, capable of sustaining the blood level without deteriorating the absorbability and useful as an antihypertensive agent sufficiently effective by one administration a day, by adding a solution of a water-insoluble substance in an organic solvent to a mixture of prazosin with a dissolution accelerating substance and excipient and granulating the resultant blend. CONSTITUTION:A sustained release granule of prazosin, obtained by adding a solution of a water-insoluble substance dissolved in an organic solvent to a mixture of prazosin with a dissolution accelerating substance, e.g. enteric base, cyclodextrin, nonionic surfactant, etc.) and excipient and granulating the resultant blend and having nondisintegrating property. Ethyl cellulose having 5-100cP viscosity at 20 deg.C and 44-51wt% ethoxy group content, hardened oil, etc., may be preferred for the water-insoluble substance, which forms a drug holding structure and prevents the disintegration of the granule in digestive juice. The dissolved prazosin is sustainedly released since it diffuses interstices between the water-insoluble substance in a weaving way.
|
