| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for synthesizing macrolide antibiotics, etc., in high yield and selectively, by reacting a specific aluminum compound with an aldehyde in the presence of a stannous compound and a pyrrolidine compound in an organic solvent. CONSTITUTION:A compound shown by formula I (R<1>-R<5> are H, 1-10C alkyl, aryl or aralkyl) is reacted with a compound shown by formula R<6>-CHO (R<6> is 1-10C alkyl, aryl or aralkyl) in the presence of a compound shown by formula II (X and Y are halogen or sulfonic acid residue) and a compound shown by formula III [R<7> is H or 1-5C alkyl; R<8> and R<9> are 1-10C alkyl, aryl or mutually bonded to give 2-5C alkylene chain; steric configuration of asymmetric carbon shown by * is (S)] in an organic solvent (e.g., toluene, THF or methylene chloride) at -100-25 deg.C to give the aimed compound shown by formula IV. The aimed compound is obtained by a short process in high yield and high selectivity without using an optically active allylating agent which already contain an asymmetric source. |
