| 摘要 |
Compounds having the formula <IMAGE> wherein R1 and R2 are each independently hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl ring; R3 is hydrogen or alkyl; R4 is hydrogen or alkyl, and R5 is hydrogen, alkyl, phenyl, substituted phenyl, a 4,5,6 or 7-membered heterocycle, phenylalkyl, (substituted phenyl)alkyl, (4,5,6 or 7-membered heterocycle)alkyl, <IMAGE> +TR <IMAGE> or together R4 and R5 are =CH-Y7; wherein Y1 is hydrogen, alkyl, phenyl, substituted phenyl, methylcarbonyl, trifluoromethylcarbonyl, phenylcarbonyl, (substituted phenyl)carbonyl, carboxymethyl, methylsulfonyl, phenylsulfonyl, (substituted phenyl)sulfonyl, aminocarbonyl, aminocarbonylamino, aminoethyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, phenylcarbonylamino, (substituted phenyl)carbonylamino, 1-pyrrolidinyl or 1-piperidinyl; Y2 is hydrogen, alkyl, phenyl, substituted phenyl, a 4,5,6 or 7-membered heterocycle, alkoxy, formyl, carbonyl, aminocarbonyl, aminothiocarbonyl, methylaminocarbonyl, methylaminothiocarbonyl, trifluoromethyl, phenylmethyl, (substituted phenyl)methyl, phenyloxymethyl, (substituted phenyl)oxymethyl, cyanomethyl, hydroxymethyl, alkoxymethyl, aminomethyl, methylcarbonylaminomethyl, aminocarbonylaminomethyl, methylsulfonylaminomethyl, carboxymethyl, aminocarbonylmethyl, alkoxycarbonylmethyl, (4,5,6 or 7-membered heterocycle)-alkyl, hydroxyaminocarbonylmethyl, or azidomethyl; Y3 is amino, alkyl, alkylthio, carboxythio, alkoxycarbonylthio or aminocarbonylthio; Y4 is alkyl, amino, hydroxyamino, alkoxyamino, methylcarbonylamino, or phenylcarbonylamino; Y5 is hydrogen or alkyl; Y6 is hydrogen, alkyl, carboxymethyl, or aminocarbonylmethyl; and Y7 is phenyl or substituted phenyl; are useful chemical intermediates for the preparation of beta -lactam antibiotics.
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