| 摘要 |
NEW MATERIAL:A compound shown by formula I {R1 is group shown by formu la II or formula III (A ring is benzene ring or cyclohexane ring; Y and Z are both H or bonded to form single bond, O, S, CH=CH, CH2-CH2, etc.,; R4 and R5 are H, halogen, alkyl, etc.,); R2 is H, alkyl or alkoxy; R3 is phenylalkyl wherein alkyl part is substituted with OH, diphenylmethyl, naphthyl, aromatic heterocyclic, etc.,; W is carbonyl or sulfonyl; X is alkylene; a is 2 or 3] or its salt. EXAMPLE:11-[4-(4-Cinnamyl-1-piperazinyl)butyrylamino]-6,11-dihydrobenz o[b,e] thiepin. USE:Having improved calcium antagonism, useful for preventing and remedying ischemic diseases of circulatory organs and hypertension, having an antiallergic action. PREPARATION:For example, a compound shown by formula IV (V is alcohol reactive residue) is reacted with a compound shown by formula V preferably in the presence of a base to give a compound shown by formula I. |
