发明名称 |
Macrocyclic bifunctional chelating agents |
摘要 |
A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.
|
申请公布号 |
US4678667(A) |
申请公布日期 |
1987.07.07 |
申请号 |
US19850751769 |
申请日期 |
1985.07.02 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MEARES, CLAUDE F.;DENARDO, SALLY J.;COLE, WILLIAM C.;MOL, MIN K. |
分类号 |
A61K47/48;A61K49/08;A61K51/04;A61K51/08;A61K51/10;(IPC1-7):A61K39/00;A61K39/42;A61K43/00;A61K49/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|