| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [X1 and X2 are H, halogen, CF3 or NO2; Y is group shown by formula II (R is H, halogen or CF3), group shown by formula III or group shown by formula IV; with the proviso that X1 and/or X2 are NO2 when Y is group shown by formula II]. EXAMPLE:N-( 2-Nitrobenzoyl )-N'-[ 4-( 5-bromo-2-pyrimidinyloxy )-3-nitrophenyl]urea. USE:A drug and an anti-cancer drug. Showing improved anti-cancer action without causing side effects by administration method or administration form, being administered as an injection for intra-abdominal injection, intravenous injection and local administration, etc., in the case of animals, an injection for blood injection to vein or artery or for local administration or as an oral drug or a suppository in the case of human. PREPARATION:A compound shown by formula V (R1 is isocyanate or amino) is reacted with a compound shown by formula VI (R2 is amino or isocyanate and different from R1) in a solvent to give a compound shown by formula I.</p> |
