发明名称 |
ANTIBODY ENHANCEMENT OF IMMUNOGENICITY OF ANTIGEN |
摘要 |
<p>Methods and compositions for enhancing an immune response of T lymphocytes to antigen are described. Complexes of antigen and antibody specific therefor, formed with a molar excess of antibody, augment proliferative and effector function response fo antigen-specific T lymphocytes in vitro. Monoclonal antibody of the IgG1 or IgG2a subclass exhibit the greatest enhancing capability. Antigen-antibody complexes can be used to potentiate in vitro activation and clonal expansion of antigen-specific T lymphocytes. Further, complexes of antigen and monoclonal IgG1 or IgG2a antibody specific for the antigen may be used to formulate more efficient vaccine for vaccination in vivo.</p> |
申请公布号 |
EP0153871(A3) |
申请公布日期 |
1987.07.01 |
申请号 |
EP19850301388 |
申请日期 |
1985.02.28 |
申请人 |
CENTOCOR, INC. |
发明人 |
CHANG, TSE WEN;CELIS, ESTEBAN |
分类号 |
C12N15/02;A61K38/00;A61K38/21;A61K39/00;A61K39/29;A61K39/395;A61K39/42;C07K16/08;C12P21/08;(IPC1-7):A61K39/00;C12N15/00;C12N5/00 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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