发明名称 |
Yeast production of hepatitis B Surface antigen. |
摘要 |
<p>Novel DNA constructs comprising regulatory regions plus the structural coding region for hepatitis B surface antigen (HBsAg) are disclosed. The regulatory regions employed are responsive to methanol, non-catabolite repressing carbon sources and catabolite repressing carbon sources followed by carbon source starvation. The novel constructs are incorporated into a variety of linear and circular plasmids. Such plasmids are used to transform suitable hosts and ultimately used for the production and isolation of hepatitis B surface antigen in high yields. </p> |
申请公布号 |
EP0226846(A1) |
申请公布日期 |
1987.07.01 |
申请号 |
EP19860116302 |
申请日期 |
1986.11.25 |
申请人 |
PHILLIPS PETROLEUM COMPANY |
发明人 |
TSCHOPP, JUERG FRIEDRICH;HARPOLD, MICHAEL MILLER;CREGG, JAMES MICHAEL;BUCKHOLZ, RICHARD GORDON |
分类号 |
C12N15/09;A61K39/29;C07H21/04;C07K14/02;C12N1/16;C12N1/19;C12N15/00;C12N15/51;C12N15/81;C12P21/00;C12R1/84;(IPC1-7):C12N15/00;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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