发明名称 |
1-(6-(2'-substiuted-5', 6', 7', 8'-tetrahydro-4',-oxo-quinazolino))-3-4-dihydro-6,7-disubstituted-isoquinoline derivatives and pharmaceutical compostions containing them |
摘要 |
The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoqu inoline derivatives of the formula (I) <IMAGE> (I) wherein R1 and R2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group, and acid addition and quaternary salts thereof. Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.
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申请公布号 |
US4677109(A) |
申请公布日期 |
1987.06.30 |
申请号 |
US19850721807 |
申请日期 |
1985.04.10 |
申请人 |
RICHTER GEDEON VEGYESZET GYAR |
发明人 |
BERNATH, GABOR;KOBOR, JENO;LAZAR, JANOS;MOTIKA, GABOR;EZER, ELEMER;HAJOS, GYORGY;PALOSI, EVA;DENES, LASZLO;SZPORNY, LASZLO |
分类号 |
A61K31/505;A61K31/535;A61P25/04;A61P25/08;A61P29/00;A61P39/02;C07D401/04;C07D401/14;(IPC1-7):A61K31/505 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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地址 |
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