PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES

摘要

Cephalosporin, useful as antimicrobial agent, was prepd. Thus, 3.36g of reagent obtained from a mixt. contg. boron trifluoride in sulfolane, methylene chloride and 2-(2aminothiazol-4-yl)-2-(syn)- methoxyiminoacetamide was reacted with 4.10g pivaloyloxymethyl-7- amino-3-(5-methyl-1,2-3,4-tetrazol-2-yl) methyl- 3-cephem-4- carboxylate in 41 ml ethylacetate at room temp. for 3h to give 7.18g pivaloyloxymethyl 7-[2-(2-aminothiazol -4-yl)-2-(syn)- methoxyiminoacetamide -3-(5-methyl-1,2,3,4-tetrazol -2-yl) methyl- 3-cephem-4-carboxylate.