| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R represents H, halogen atom or 1-3C alkyl). EXAMPLE:2-[2-(3,5-Dimethyl-4-methoxy)pyridylmethylthio]-6-bromoimidazo [4,5-b] pyridine. USE:A remedy for gastric and duodenal ulcers. PREPARATION:A 2-mercaptoimidazopyridine derivative expressed by formula II (example; 2-mercaptoimidazo[4,5-b]pyridine, etc.) is condensed with a pyridine derivative expressed by formula III (X represents Cl or Br) (example; 2- chloromethyl-3,5-dimethyl-4-methoxyphridine hydrochloric acid, etc.) in a reaction solvent using a base to obtain a 2-[2-(3,5-dimethyl-4-methoxy) pyridylmethylthio]imidazopyridine derivative, which is oxidized with an oxidizing agent (preferably m-chloroperbenzoic acid) in the presence of the reaction sol vent.
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