| 摘要 |
PURPOSE:To provide an immobilizing agent for phosphate ion, composed of a carbonate or an organic acid compound of a rare earth element, selectively and irreversibly reacting with phosphate ion in high efficiency especially under the pH condition in the digestive tract and blood of living body and effective for remedying hyperphosphatemia, etc. CONSTITUTION:A carbonate or an organic acid compound of a rare earth element (e.g. Y, La, Ce, Pr, etc.) is used as an immobilizing agent for phosphate ion. Concrete examples of the compound are cerous oxalate decahydrate, cerous citrate 3.5 hydrate, etc. The immobilizing agent of the present invention immobilizes and removes phosphate ion almost completely at >=6pH. The performance is uninfluenced by the presence of other anions such as chlorine ion, bicarbonate ion, etc., to enable the selective immobilization and removal of phosphate ion. The immobilization capacity to phosphate ion per unit weight of the agent is >=5 times the conventional adsorption agent and, accordingly, the amount of the agent can be reduced. |
