| 摘要 |
NEW MATERIAL:The dipeptide derivative of formula I (m is 1-8; n is 1-6; R<1> is H; R<2> is H, 3-5C branched alkyl, phenyl, hydroxyphenyl, indolyl, imidazolyl, methylthio or R<1> and R<2> together form a bond between carbon and nitrogen atoms; R<3> is lower alkyl ester, hydroxymethyl or formyl). EXAMPLE:N-(4-phenylbutanoyl)-Pro-Pro-OMe. USE:It has remarkable antiendoprolylpeptidase activity and antiamnesic activity and is useful as a preventive and remedy for amnesia. It has high safety and is administered by oral or parenteral administration. PREPARATION:The compound of formula I can be produced e.g. by reacting the carboxylic acid, acid halide, etc., of formula II (A is hydroxyl group, halogen or group of formula III) with the peptide ester derivative of formula IV (B is lower alkyl) in the presence of a base and reducing the reaction product. |
