| 摘要 |
NEW MATERIAL: A phenylpyridazinone derivative expressed by formula I [R1 and R2 are H or lower alkyl; R3 is (NH)n-NHR6 (R6 is 1-10C alkyl, heteroaryl, etc., having 1-2 substituent groups), NH-NHR7 (R7 is arylacyl or heterocyclylacyl); R4 and R5 are H, lower alkyl, halogen lower alkyl, halogen, lower alkoxy, etc,; Q is O or S; A is 1-6C alkylene; the bond containing the dotted line is single bond] and a salt thereof. EXAMPLE:6-[3-Chloro-4-[N-(2-piperazinoethyl)carbamoylmethoxy]phenyl]4, 5-dihy dro-3(2H)-pyridazinone. USE:Useful as a cardiotonic agent, antihypertensive agent, remedy for thrombotic and embolitic diseases, etc., and capable of oral administration. PREPARATION:For example, as shown in the reaction formula, a compound expressed by formula II as a starting material is passed through three steps to afford the aimed compound expressed by formula I. |
