| 摘要 |
<p>Process for the preparation of compounds of general formula (I), and pharmaceutically acceptable salts thereof (wherein R stands for piperazinyl or 4-methyl-piperazinyl) which comprises reacting a compound of general formula (II), (wherein R?1 and R2¿ stand for halogen; an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or an aromatic acyloxy group comprising 7-11 carbon atoms) with a piperazine of general formula (III), (wherein R3 represents hydrogen or methyl) or a salt thereof, hydrolysing the compound of general Formula (IV), thus obtained (wherein R, R?1 and R2¿ are as stated above) without or after hydrolysis and if desired converting the compound of general formula (I) thus obtained into a salt thereof or setting free the same from its salt. The compounds of general formula (I) are known antibacterial agents. The advantage of the process of the present invention is that it enables the preparation of the compounds of general formula (I) in a simple manner, with high yields and in a short reaction time.</p> |
