| 摘要 |
<p>NEW MATERIAL:The compound of the formula. It has following physical and chemical properties: molecular weight: 10,700; thermal stability: 75% residual activity after heat treatment at 120 deg.C for 10min; stable at pH: 4-11. USE:Antimycotic. It has high thermal resistance and high stability to pH. PREPARATION:A yeast in Hansenula, e.g., Hansenula mrakii (IFO 0895) is cultured in an enriched medium which the yeast assimilate by the shaking culture at 30 deg.C for 24hr, then the culture mixture is concentrated. The concentrate is subjected to the column chromatography filled with Sepharose to which the anti-K9 killer toxin monoclonal antibody is activated and immobilized. The eluate fractions are collected, dialyzed in distilled water to give the objective substance.</p> |
